Use of higher starting doses in patients who are not opioid tolerant may cause fatal respiratory depression. Important Administration Instructions Instruct patients how to properly take avinza, including the following: Swallowing avinza capsules whole or sprinkling the capsule contents on applesauce and then swallowing immediately without chewing Not crushing, chewing, or dissolving the pellets in the capsules Using avinza exactly as prescribed. In controlled and open-label clinical studies, 560 patients with chronic malignant or non-malignant pain were treated with avinza. Adjust the dose to obtain an appropriate balance between management of pain and opioid-related adverse reactions. M6G has been shown to have analgesic activity but crosses the blood-brain barrier poorly, while M3G has no significant analgesic activity.
The AUC is increased and clearance is decreased and the metabolites, M3G and M6G, may accumulate to much higher plasma levels in patients with renal failure as compared to patients with normal renal function. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. For more information go.gov Instructions For Use avinza (ah-ven-zah) (morphine sulfate) extended-release Capsules If you cannot swallow avinza capsules, tell your healthcare provider.
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